Type 2 diabetes (T2D) is increasing among youth, and is associated with extremely high rates of complications. We recently demonstrated that 30% of youth with T2D develop albuminuria within 4 years of diagnosis, and ≥ 50% progress to end-stage kidney disease before age 40. The iCARE Cohort Study is designed to understand why youth living with type 2 diabetes develop complications at higher rates than youth with type 1 diabetes and why the complications appear to be more aggressive.
This project is led by Dr. Allison Dart, a member of the DREAM theme and pediatric nephrologist at the Winnipeg Children's Hospital. The project is currently restricted to studying youth in Manitoba, however there are plans to expand this to a national network focused on the bio-psychological determinants of complications associated with type 2 diabetes in youth. Dr. Dart has made several key discoveries regarding the high rates of complications in youth with type 2 diabetes which can be found here.
The overall aim of this project is to elucidate the primary bio-psycho-social (BPS) risk factors for albuminuria in youth with T2D and the mechanisms by which they cause renal injury. To accomplish this aim, we will create a multi-ethnic national cohort of youth with T2D to address the following specific research aims: Aim 1: Characterize the primary BPS risk factors associated with prevalent and progressive albuminuria in youth with T2D. Aim 2: Determine individual, family and community level factors that influence biological and psychological risk factors and behaviors (adherence) that could be modified to protect against renal complications. Aim 3: Explore the interrelationship between systemic and renal inflammatory biomarkers and albuminuria, which may be the common pathway between BPS risk factors and albuminuria.